中药汤剂结合常规西药治疗变应性鼻炎疗效的Meta分析

目的 通过Meta分析探究中药汤剂结合常规西药治疗变应性鼻炎的近期疗效与远期疗效。 方法 计算机检索中国期刊全文数据库、万方数据库、中国科技期刊全文数据库、中国生物医学文献数据库、Pubmed、Embase、The Cochrane Library数据库中关于中西医结合治疗变应性鼻炎临床研究的随机对照试验,检索时间从建库至2020年10月。由两位专业研究员进行质量评价并提取相关数据后,采用RevMan 5.3软件和Stata 15.0 软件进行Meta分析。 结果 最终纳入19个研究,共计1 980例患者,采用固定效应模型进行总效应值合并, Meta分析结果显示:中药汤剂结合常规西药治疗变应性鼻炎的近期有效率显著优于对照组［RR=1.18,95%CI(1.13,1.22),P<0.001］,远期有效率显著优于对照组［RR=1.79,95%CI(1.50,2.13),P<0.001］,并且分类后补益肺气法、健脾益气法和清宣肺气法结合常规西药治疗的近期有效率均优于对照组,Meta分析结果分别为［RR=1.17,95%CI(1.11,1.23),P<0.001］,［RR=1.18,95%CI(1.09,1.29),P<0.001］,［RR=1.18,95%CI(1.10,1.26),P<0.001］,差异均具有统计学意义,本研究漏斗图显示左右基本对称,并且通过begg偏倚检验,得出P=0.069>0.05,提示本次研究选择的19篇文献存在的发表偏倚较小。 结论 中药汤剂结合常规西药治疗变应性鼻炎的近期疗效和远期疗效均优于单纯的西医治疗。

Meta-analysis of the curative effect of traditional Chinese medicine decoction combined with conventional western medicine on allergic rhinitis

Objective Meta-analysis was conducted to explore the influence of combined Chines decoctione and conventional western medicine on the short-term and long-term efficacy of allergic rhinitis. Methods Computer retrieval Chinese National Knowledge Infrastructure(CNKI), Wan Fang Data, VIP, CBM, Pubmed, Embase, The Cochrane Library databases of combining traditional Chinese and western medicine treatment of allergic rhinitis in clinical research of randomized controlled trials, from building Library retrieval timeuntil October 2020. After quality evaluation and relevant data extraction by two professional researchers, RevMan5.3 software and Stata 15.0 software were used for Meta analysis. Results In the end into the 20 research, a total of 2056 patients, using fixed effect model to the total effect value to merge, Meta analysis results show that the recent effective rate of combining traditional Chinese decoctione and conventional western medicine treatment of allergic rhinitis was superior to that of control group ［RR=1.18, 95%CI(1.13,1.22), P<0.001］, long-term effectiveness significantly better than control group ［RR=1.79, 95%CI(1.50,2.13), P<0.001］, After classification, the short-term effective rates of tonifying fei-qi method, fortifying the Spleen and boosting qi method and Qingxuan-fei-qi method combined with conventional western medicine were all better than those of the control group. Meta-analysis results were ［RR=1.17, 95%CI(1.11,1.23), P<0.001］,［RR=1.18, 95%CI(1.09,1.29), P<0.001］,［RR=1.18, 95%CI(1.10,1.26), P<0.001］, respectively. the difference is statistically significant. In this study, funnel plot showed the basic symmetry between the left and the right, and the begg bias test was used to obtain P=0.069>0.05 means that the publication bias of the 19 literatures selected in this study is small. Conclusion This study shows that the combined treatment of Chinese medicine decoction and conventional western medicine for AR is superior to the treatment of western medicine alone in both short-term and long-term efficacy.