基于表型和内在型的慢性鼻窦炎诊治进展

慢性鼻窦炎(CRS)是一种具有复杂表型和内在型的异质性疾病。根据是否有鼻息肉,CRS的表型可分为伴或不伴息肉。CRS的其他表型分类还包括是否伴有过敏、哮喘、阿司匹林不耐受等。近年来,关于CRS内在型致病机制的研究如2型炎症和非2型炎症取得突破性进展,为CRS的治疗引入了有效的生物制剂。阐述慢性鼻窦炎最新表型和内在型分类和基于表型和内在型的最新治疗进展,为临床更好地结合内在型和表型,对慢性鼻窦炎更精确的诊断和更精准的个性化治疗提供思路。

Advancements in the diagnosis and treatment of chronic sinusitis based on phenotypes and endotypes

Chronic rhinosinusitis(CRS)is a heterogeneous disease with complex phenotypes and endotypes. Depending on the presence or absence of nasal polyps, CRS phenotypes can be classified as with or without polyps. Other phenotypic classifications of CRS include allergies, asthma, and aspirin intolerance. In recent years, breakthroughs have been made in research on the pathogenesis of CRS endotypes, such as type 2 inflammation and non-type 2 inflammation, and effective biological agents have been introduced for the treatment of CRS. This article describes the latest phenotype and endotype classification of chronic rhinosinusitis and the latest treatment progress based on phenotypes and endotypes. The identification of specific endotype and phenotype combinations will allow more accurate diagnoses of chronic rhinosinusitis and personalized treatments in the future.