慢性鼻窦炎发病中离子通道作用研究进展

慢性鼻窦炎(CRS)是鼻科目前常见的慢性炎症性疾病,其病因及发病机制尚未完全明确。离子通道参与稳定细胞膜电位、维持细胞液体平衡和调节细胞间信号转导等多种生理活动。目前研究发现钙离子通道、钾离子通道、钠离子通道、氯离子通道及氢离子相关离子通道等与CRS发病密切相关。大量研究发现在CRS的鼻黏膜组织中离子通道表达异常,提示离子通道调控紊乱可能参与CRS的炎症免疫反应过程并导致CRS进一步加重。本文就离子通道在CRS发病中作用的研究进展进行综述,以期为下一步深入探索CRS发病机制及治疗方案提供新的思路。

The roles of ion channels in the pathogenesis of chronic rhinosinusitis

Chronic rhinosinusitis(CRS)is a common chronic inflammatory disease in rhinology; its etiology and pathogenesis are not fully understood. Ion channels are proposed to participate in a variety of physiological activities, such as stabilizing membrane potential, maintaining cellular volume homeostasis, regulating intercellular signal transduction, and other functions. Calcium channels, potassium channels, sodium channels, chloride channels and hydrogen ion-related ion channels are closely related to the pathogenesis of CRS. Numerous studies have shown that ion channels are abnormally expressed in nasal mucosa tissues from CRS patients, indicating that disturbance of ion channel regulation may be involved in the inflammatory immune response of CRS and lead to its further aggravation. This review summarizes research progress on the roles of ion channels in the pathogenesis of CRS. The aim is to provide new insights into further explorations of CRS pathogenesis and treatment strategies.