单核细胞趋化蛋白-1-2518G/A位点基因多态性与糖尿病肾病易感性的Meta分析

目的 评估单核细胞趋化蛋白-1(MCP-1)-2518G/A基因多态性与糖尿病肾病(DN)发病风险的关系.方法 系统检索PubMed、Web of Science、EMbase、Cochrane Library、中国知网(CNKI)、万方和维普数据库中截至2016年10月收录的所有有关MCP-1-2518G/A基因多态性与DN发病风险的文献.提取相关数据,应用STATA11.0统计软件计算合成数据的比值比(OR)和95%可信区间(CI),同时评估研究的异质性、发表偏倚.结果 共纳入的9项研究涉及2767例独立样本,其中病例组为1096例,对照组为1671例.对于总体人群,在4个基因模型中均未发现MCP-1-2518G/A多态性与DN发病风险有关(显性模型:OR=1.01,95%C I:0.67~1.54;隐性模型:OR=0.93,95%C I:0.60~1.44;纯合子模型:OR=0.93,95%C I:0.70~1.23;杂合子模型:OR=0.89,95%CI:0.61~1.31).亚组分析结果显示,在印度人群中,MCP-1-2518G/A基因多态性会显著增加DN的发病风险(显性模型:OR=1.56,95%CI:1.19~2.06),但在中国人、土耳其人及韩国人中均未发现MCP-1-2518G/A基因多态性与DN的发病风险有关.结论 总体人群中,MCP-1-2518G/A位点基因多态性与DN发病风险无关,但MCP-1-2518G/A位点多态性会增加印度人群DN发病风险,而不增加中国人群、韩国人群、土耳其人群中DN的发病风险.

Meta analysis on MCP-1-2518G/A gene polymorphism and susceptibility of diabetic nephropathy

Objective To evaluate the relation between MCP-1-2518G/A gene polymorphism and the onset risk of diabetic nephropathy(DN) by the data of collected and publishedcase control studies and using the meta analysis method .Methods All lit-eratures on moncyte chemoattractant protein-1(MCP-1)-2518G/A gene polymorphism and the onset risk of DN included in the da-tabases of PubMed ,Web of Science ,EMbase ,Cochrane Library ,CNKI ,Wanfang and VIP until October 2016 were systametically re-trieved .Then the related data were extracted .The Stata11 .0 statistical software was used to calculate the odds ratio (OR) of syn-thetic data and 95% confidence interval (CI) ,meanwhile the heterogeneity and publication bias of the studies were evaluated .Re-sults A total of 9 studies were included involving 2767 independent samples ,the number of cases was 1096 ,the control number was 1671 .For the general population ,the relationship between MCP-1 gene-2518G/A polymorphism and the onset risk of DN was not found in 4 gene models (dominant model:OR=1 .01 ,95% CI:0 .67-1 .54 ;recessive model :OR=0 .93 ,95% CI:0 .60-1 .44 ;homo-zygous model:OR=0 .93 ,95% CI:0 .70 -1 .23 ;heterozygous model :OR=0 .89 ,95% CI:0 .61-1 .31) .The subgroup analysis re-sults showed that in India population ,MCP-1-2518G/A gene polymorphism might significantly increase the onset risk of DN (domi-nant model:OR=1 .56 ,95% CI:1 .19 -2 .06) ,but in Chinese ,Turks or South Koreans ,the MCP-1-2518G/A gene polymorphism had no relation with the onset risk of DN .Conclusion In the general population ,MCP-1-2518G/A gene polymorphism has no rela-tion with the onset risk of DN .But the MCP-1 gene-2518G/A polymorphism can increase the onset risk of DN in India population , while does not increase the onset risk of DN in Chinese population ,Korean population and Turkey population .