GP方案与NP方案治疗晚期非小细胞肺癌对比观察

目的比较GP方案与NP方案治疗晚期非小细胞肺癌的疗效和毒性反应。方法56例晚期非小细胞肺癌随机分为两组,GP组29例,吉西他滨1.0～1.2g/m^2,第1、第8天,静脉滴注;顺铂25mg/m^2,第1～3天,静脉滴注。NP组27例,长春瑞滨25mg/m^2,第1、第8天,静脉推注;顺铂25mg/m^2,第1～3天,静脉滴注,21d为1个周期,治疗2个周期以上评定疗效,同时予水化、利尿等处理。结果GP组有效率44.8%,NP组有效率40.7%,两组差异无显著性（P〉0.05）。骨髓抑制为两组的主要毒性反应,其中NP组白细胞下降发生率高于GP组（85.2%对51.7%,P〈0.05）,GP组血小板下降发生率高于NP组（82.8%对22.2%,P〈0.05）,NP组静脉炎反应较GP组重（29.6%对6.9%,P〈0.05）,两组比较差异有显著性。结论GP方案与NP方案治疗晚期非小细胞肺癌疗效显著,毒性反应各异,但可耐受。

The comparison between GP and NP regimens for treatment of advanced non-small cell lung cancer

Objective To compare the efficacy and toxicity between GP(gemcitabine +cisplatin) regimen and NP(vinorelbine + cisplatin) regimen in the treatment of advanced non-small cell lung cancer(NSCLC).Methods Fifty-six cases of advanced NSCLC were enrolled:29 cases were treated with GP regimen(GEM 1.0-1.2 g/m2,ivgtt d1 and d8,DDP 25 mg/m2,ivgtt d1-3),27 cases were treated with NP regimen(NVB 25 mg/m2,iv d1 and d8,DDP 25 mg/m2,ivgtt d1-3).The treatment in two groups was repeated every three weeks and the efficacy wa...