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Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia
Authors:Claudia R. Morris  Hae‐Young Kim  Elizabeth S. Klings  John Wood  John B. Porter  Felicia Trachtenberg  Nancy Sweeters  Nancy F. Olivieri  Janet L. Kwiatkowski  Lisa Virzi  Kathryn Hassell  Ali Taher  Ellis J. Neufeld  Alexis A. Thompson  Sandra Larkin  Jung H. Suh  Elliott P. Vichinsky  Frans A. Kuypers  the Thalassemia Clinical Research Network
Affiliation:1. Department of Pediatrics, Division of Emergency Medicine, Emory University School of Medicine, Emory Children's Centre for Cystic Fibrosis and Airways Disease Research, Atlanta, GA, USA;2. New England Research Institutes Watertown, Watertown, MA, USA;3. The Pulmonary Centre, Boston University School of Medicine, Boston, MA, USA;4. Children's Hospital of Los Angeles, Los Angeles, CA, USA;5. University College London, London, UK;6. Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA;7. Toronto General Hospital, Toronto, ON, Canada;8. Children's Hospital of Philadelphia, Philadelphia, PA, USA;9. Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA;10. American University of Beirut, Beirut, Lebanon;11. Children's Hospital Boston, Boston, MA, USA;12. Haematology, Oncology & Stem Cell Transplant, Children's Memorial Hospital, Chicago, IL, USA;13. Children's Hospital Oakland Research Institute, Oakland, CA, USA
Abstract:
Keywords:arginase  β  ‐thalassaemia  global arginine bioavailability ratio  haemolysis  pulmonary hypertension
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