慢性乙型肝炎多重病毒感染临床特征研究

目的慢性乙型肝炎多重病毒感染临床并不多见，可使肝炎的病程变得较为复杂，预后相对较差，国内外相关的文献报道较少。分析慢性乙型肝炎多重病毒感染的病原学类型并研究其临床特征。方法共有慢性乙型肝炎多重病毒感染88例，其中三重感染74例，四重感染14例；用日期随机法抽取同期单纯乙型肝炎100例作为对照组。结果乙型肝炎多重病毒感染患者中合并丁肝病毒（HDV）、巨细胞病毒（CMV）、甲肝病毒（HAV）与戊肝病毒（HEV）者较多，分别为84．1％、43．2％、33．0％、26．1％。多重病毒感染患者的肝功能损害明显较单纯感染者重，疗效差，住院时间长。结论与慢性乙型肝炎单纯感染相比，慢性乙型肝炎多重病毒感染肝功能损害严重，疗效较差。

Clinical characteristics of multiple virus infections in patients with chronic hepatitis B

Objectives Chronic hepatitis B accompanied by multiple virus infection can result in more complicated process and worse prognosis, which is clinical rare. There are just a few related literatures on it. To analyse the virological categories of multiple virus infection in patients with chronic hepatitis B and to evaluate its clinical features.Methods The virological and clinical features in 88 patients with chronic hepatitis B accompanied by multiple viruses, which included 74 cases with three types of viruses and 14 cases with four types of viruses, Which were analysed and compared with those in 100 patients only with hepatitis B. Results The percents of patients with hepatitis D virus (HDV), cytomegalovirus (CMV), hepatitis A virus (HAV) and hepatitis E virus (HEV) infections in 88 patients were 84.1%, 43.2%, 33.0%, 26.1%, respectively. The liver function injury was more severe in the patients with multiple virus infections, which was accompanied by poorer effectiveness and longer period of hospitalization.Conclusions The patients with chronic hepatitis accompanied by multiple viruses have more severe liver function injury and poorer effectiveness compared with those single virus infection.