Anterograde transport of HSV-1 and HSV-2 in the visual system. |
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Authors: | R B Norgren J H McLean H C Bubel A Wander D I Bernstein M N Lehman |
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Affiliation: | Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, OH 45267-0521. |
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Abstract: | The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system. |
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