| 光纤药物在位溶出度／释放度监测仪实时监测复方盐酸阿米洛利片体外溶出度 |
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| 引用本文： | 吴军,李新霞,陈坚.光纤药物在位溶出度／释放度监测仪实时监测复方盐酸阿米洛利片体外溶出度[J].药物分析杂志,2007,27(2):238-241. |
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| 作者姓名： | 吴军 李新霞 陈坚 |
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| 作者单位： | 新疆医科大学公共卫生学院，新疆医科大学药学院 |
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| 基金项目： | 新疆维吾尔自治区高技术发展计划资助项目（200311110） |
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| 摘 要： | 目的:采用光纤化学传感技术实时、在位监测固体制剂体外溶出度的测定并与2000年版中国药典方法比较。方法:应用光纤原位药物溶出度/释放度试验仪,将分支光纤一端连接光源,公共端部探头浸入溶出液;另一端连接检测器,计算机记录并处理数据。结果:本法监测药物溶出的全过程,显示药物实时溶出曲线图,直接提取相关参数,与药典方法比较,无统计学差异(P>0.05)。结论:光纤化学溶出度过程监测法能够有效地测定固体药物的体外溶出度,并能真实地反映药物溶出的全过程。
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| 关 键 词： | 光纤溶出度/释放度过程监测法 药典溶出度测定方法 复方盐酸阿米洛利片 |
| 文章编号： | 0254-1793（2007）02-0238-04 |
| 修稿时间： | 2006-06-06 |
The real- time optic fiber chemical sensor dissolution test detection method and conditions for compound amiloride hydrochloride tablets |
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| WU Jun , LI Xin - xia, CHEN Jian.The real- time optic fiber chemical sensor dissolution test detection method and conditions for compound amiloride hydrochloride tablets[J].Chinese Journal of Pharmaceutical Analysis,2007,27(2):238-241. |
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| Authors: | WU Jun LI Xin - xia CHEN Jian |
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| Institution: | 1. College of Public Health, Xinjiang Medical University, Ummqi 830054, China; 2. College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China |
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| Abstract: | Objective:To study a method which can monitor the dissolution rate of drug on-line-fiber optic chemical sensor dissolution test(FOCSDT).And compare the difference of this method with CHP(2000).Method: By mean of FOCSDT,bifurcated optical fiber was used to connect light source and detector and the common end was dipped in the dissolution vessel.The dissolution procession could be monitored through computer.Result:This pro- cession analysis could test the whole process of drug and get dissolution graph.The parameters obtained by FOCSDT had no significant difference compared with the method in ChP 2000(P>0.05).Conclution:This procession anal- ysis can reflect the real dissolution of drug and obtain the total information. |
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| Keywords: | fiber optic chemical sensor dissolution test(FOCSDT) ChP(2000)dissolution test compound amiloride hydrochloride tablets |
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