Suppression of insulin-induced prolactin secretion in man by nomifensine

In 12 healthy male volunteers we studied the effect of nomifensine, an inhibitor of endogenous catecholamine reuptake, on insulin-induced prolactin and growth hormone (GH) secretion. The effect of the drug on TRH-induced prolactin secretion was also studied. Nomifansine was able to suppress completely the insulin-stimulated prolaction secretion, whereas no effect on GH secretion was observed. TRH-induced prolactin secretion was uninfluenced by the drug.