多虑平对心理应激大鼠血浆胃动素与血管活性肠肽水平的影响

目的 研究多虑平对心理应激大鼠相关胃肠激素的影响.方法 刺激经6-羟多巴胺预处理的大鼠攻击受试大鼠作为心理应激源,检测受试大鼠血浆胃动素(MTL)、血管活性肠肽(VIP)的改变.结果 模型组大鼠血浆MTL、VIP水平分别为(318.5±89.37)pg/ml和(65.78±12.10)pg/ml,与正常组(223.43±73.05)mg/mol,(88.27±16.90)mg/mol比较均差异有显著性(P<0.01);多虑平组大鼠血浆MTL、VIP水平分别为(267.37±80.33)pg/ml和(77.54±13.36)pg/ml,与模型组比较均差异有显著性(P<0.05).结论 强烈的心理应激可影响大鼠血浆MTL、VIP水平,多虑平可以调节心理应激大鼠的情绪状态,可减轻心理应激对大鼠血浆MTL、VIP水平的影响,从而影响结肠运动.

Effect of doxepin on levels of plasnm motilin and vasoactive intestinal peptide of psychological stress rats

Objective To study the effect of doxepin on some gut hormones of psychological stress ratsMethods To stimulate the 6-OHDA.treated rats to attack the experimental rats as social psychological stressor,and to detect the change of levels of plasma motilin(MTL) and vasoactive intestinal peptide(VIP) of experimental rats.Results The level of plasma MTL and VIP of the rats in model group were (318.5±89.37)pg/ml and(65.78±12.10)pg/ml.There were significant difference(P<0.01)between model group and normal group [(223.43+73.05)mg,/mol,(88.27±16.90)me/mol].The level of plasma MTL and VIP of the rats in control group were(267.37±80.33)pg/ml and(77.54±13.36)pg/ml.There were significant difference(P<0.05)between control group and model group. Conclusion Strong psychological stress could influence levels of plasma MTL and VIP of the rats.But Doxepin could adjust the emotional state of psychological stress rats and relieve the effect of psychological stress on levels of plasma MTL and VIP of rats,thus affect gastrointestinal motility.