| 肝硬化门静脉高压症患者血浆NO和ET-1的临床意义 |
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| 引用本文： | 唐净,王少峰. 肝硬化门静脉高压症患者血浆NO和ET-1的临床意义[J]. 江苏医药, 2005, 31(6): 425-426 |
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| 作者姓名： | 唐净 王少峰 |
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| 作者单位： | 215004,苏州大学附属第二医院 |
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| 摘 要： | 目的探讨肝硬化门脉高压患者血浆一氧化氮(NO)和内皮素1(ET-1)水平与食管静脉曲张和腹水的关系。方法76例肝硬化患者血浆NO、ET-1与其食管静脉曲张内镜评分、门静脉内径、腹水分级评分、血清白蛋白等四项指标进行非参数统计等级相关分析。结果血浆NO、ET-1与食管静脉曲张程度和门静脉内径呈正相关，与血清白蛋白呈负相关；血浆ET-1与腹水程度呈正相关。结论血浆NO和ET-1参与肝硬化门静脉高压症的病理机制。
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| 关 键 词： | 肝硬化门静脉高压症 血浆NO 临床意义 食管静脉曲张程度 肝硬化门脉高压 门静脉内径 血清白蛋白 血浆一氧化氮 血浆ET-1 肝硬化患者 非参数统计 相关分析 病理机制 正相关 内皮素 负相关 腹水 评分 |
| 修稿时间： | 2004-11-02 |
Clinical significance of plasma nitric oxide and endothelin-1 levels in cirrhotic patients with portal hypertension |
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| TANG Jing,Wang Shaofeng. Clinical significance of plasma nitric oxide and endothelin-1 levels in cirrhotic patients with portal hypertension[J]. Jiangsu Medical Journal, 2005, 31(6): 425-426 |
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| Authors: | TANG Jing Wang Shaofeng |
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| Affiliation: | TANG Jing,WANG Shaofeng.Second Affiliated Hospital,Soochow University,Suzhou 215004,CHINA |
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| Abstract: | Objective To study the relationship between plasma levels of nitric oxide(NO)and endothelin-1(ET-1) levels and the esophagus varices, ascites in cirrhotic patients with portal hypertension.Methods Correlation analysis was performed among endoscopic variceal appearances,portal vein diameter, serum albumin,ascites, plasma NO and ET-1 levels in patients with cirrhosis.Results Plasma NO and ET-1 levels were possitively correlated with endoscopic variceal appearances and portal vein diameter, and negatively correlated to serum albumin.The ascites was possitively correlated to plasma ET-1.Conclusion Plasma NO and ET-1 are involved in the pathogenesis of portal hypertension. |
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| Keywords: | Nitric oxide Endothelin-1 Portal hypertension Cirrhosis |
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