The effect of pre- and postnatal undernutrition on the calibre growth of central motor fibres |
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Authors: | Anders Sima Patrick Sourander |
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Institution: | (1) Neuropathological Laboratory, Institute of Pathology, University of Göteborg, S-41345 Göteborg, Sweden |
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Abstract: | Summary The effect of early in life instituted undernutrition on the calibre growth of cortico-spinal motor fibres was studied electron microscopically at three different developmental stages in the rat. The total diameters of these motor fibres were measured from a defined level of the medulla oblongata and plotted in histograms.In undernourished rats the calibre growth was retarded as compared to agematched control rats. Early initiated nutritional rehabilitation through controlled cross-fostering revealed that the impaired calibre growth was reversible, and thus completely restituted at the age of 180 days.It is concluded that early initiated protein-calorie undernutrition affects this central motor pathway in a similar way, as it affects a peripheral motor nerve (cf. Sima, 1974). |
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Keywords: | Undernutrition Cortico-spinal-tract Calibre spectrum |
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