维、汉两民族非小细胞肺癌患者血清中 p53抗体的表达及其临床意义

目的：探讨 p53抗体在维吾尔族（维族）、汉族非小细胞肺癌（Non-small-cell carcinoma，NSCLC）患者血清中的表达及其临床意义。方法选择诊断为非小细胞肺癌且未经放化疗、手术治疗的患者50例（病例组），其中维族、汉族患者各25例，另选取维族与汉族健康体检者（对照组）各25例。采用酶联免疫吸附试验（ELISA）检测血清中 p53抗体含量，采用全自动免疫化学发光仪检测血清常用肿瘤标志物含量，并进行比较分析。结果维族病例组 p53抗体含量高于对照组，差异有统计学意义（P ＜0．01），且抗体表达与其分化程度、TNM 分期密切相关（P ＜0．05）；汉族病例组 p53抗体含量高于对照组，差异有统计学意义（P ＜0．01），抗体表达与其分化程度、TNM 分期密切相关（P ＜0．05）；维族病例组不同病理分型 p53抗体含量比较差异有统计学意义（P ＜0．05）；但两民族病例组和对照组 p53抗体含量比较差异均无统计学意义（P ＞0．05），病例组在性别、年龄、分化程度、TNM 分期以及病理分型上均无相关性（P ＞0．05），并且两民族患者血清 p53含量与其各自血清中肿瘤标志物含量差异无统计学意义（P ＞0．05）。结论维、汉两民族非小细胞肺癌患者血清中的 p53抗体的表达情况基本一致，临床上可以考虑给予维、汉非小细胞肺癌患者相同或者相似的与 p53相关的诊断及治疗措施，同样可以根据相同或相似的 p53抗体指标来判断非小细胞肺癌患者的预后。

Study on the p53 antibody expression in non-small cell lung cancer serum of Uyghur and Han ethnic patients in Xinjiang and its elationship with the commonly used tumor markers

Objective To detect the expression of p53 antibody in the Uyghur,Han non-small cell lung cancer （Non-small-cell carcinoma,NSCLC）patients with serum,and analyze its clinical significance. Methods 50 non-small cell lung cancer patients were picked out as case group,including 25 Uyghur and Han patients respectively,who were not given chemotherapy treatment.Another 50 healthy people were＆amp;nbsp;picked out as control groups,also including 25 Uyghur and Han patients respectively.The enzyme-linked immunosorbent assay （ELISA）was used to detect the amount of p53 antibody and automatic chemilumi-nescence immunoassay was used serum to detect serum tumor markers levels.And then comparison and a-nalysis were made.Results p53 antibody results in both Uyghur and Han case groups were higher than those in control groups and the differences were statistically significant （P ＆lt;0.01）.Antibody expressions were closely related to the degree of differentiation and TNM stage,which was statistically significant （P＆lt;0.05）;p53 antibody results showed no statistical significance between Uyghur and Han case groups and control groups.Gender,age,degree of differentiation,TNM stage and pathological type in two case groups showed no correlation （P ＆gt;0.05）,and the two peoples and their respective levels of serum p53 tumor markers in serum levels were not correlated （P ＆gt;0.05）.Conclusion The serum p53 antibody ex-pressions in Uyghur and Han ethnic non-small cell lung cancer patients are basically the same.Uyghur and Han non-small cell lung cancer patients can be give the same or similar diagnosis and treatment,the prog-nostic judgment can also be the same.