| 慢性温和应激对大鼠血管内皮功能的影响 |
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| 引用本文： | 陈龙,秦纹,连玉龙,刘继文. 慢性温和应激对大鼠血管内皮功能的影响[J]. 新疆医科大学学报, 2014, 0(9): 1148-1150 |
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| 作者姓名： | 陈龙 秦纹 连玉龙 刘继文 |
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| 作者单位： | 新疆医科大学公共卫生学院,乌鲁木齐830011 |
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| 基金项目： | 国家自然科学基金（81260425） |
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| 摘 要： | 目的：探讨慢性温和应激对大鼠血管内皮功能的影响及其作用机制。方法采用孤养与慢性轻度不可预见性应激模型相结合建立慢性温和应激动物模型，随机分为实验组和对照组，采用 ELISA法检测两组大鼠血清皮质醇、细胞间黏附因子1（ICAM-1）、白介素6（IL-6）、血浆内皮素1（ET-1）的含量，透射电镜观察大鼠血管内皮超微结构的改变。结果实验组大鼠第2周和第3周体质量显著低于对照组（P ＜0．05）；血清皮质醇的含量显著增加（P ＜0．05）；血清 ICAM-1、IL-6、血浆 ET-1均较对照组明显升高（P ＜0．05）；血管内皮超微结构改变明显。结论慢性温和应激可导致大鼠血管内皮功能损伤。
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| 关 键 词： | 慢性温和应激 大鼠 血管内皮 |
Effect of chronic mild stress on vascular endothelial function in rat |
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| CHEN Long,QIN Wen,LIAN Yulong,LIU Jiwen. Effect of chronic mild stress on vascular endothelial function in rat[J]. Journal of Xinjiang Medical University, 2014, 0(9): 1148-1150 |
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| Authors: | CHEN Long QIN Wen LIAN Yulong LIU Jiwen |
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| Affiliation: | (College of Public Health, Xinjiang Medical University, Urumqi 830011, China) |
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| Abstract: | Objective To study the endothelial function damage of rat under chronic stress.Methods Enzyme linked immunosorbent assay （ELISA）was applied to determining plasma levels of ET-1,serum levels of IL-6,ICAM-1,Cortisol.The Vascular endothelial morphological changes were identified via trans-mission electron microscope.Results From the second week,the body weight of rats in the experimental group were significantly lower than the control group （P 〈0.05）.A significant increase in serum cortisol （P 〈0.05）.The content of ICAM-1,IL-6,plasma ET-1 levels were higher in experimental group than in controlled group （P 〈0.05）.Ultrastructural of Vascular endothelial were changed significantly.Conclusion Chronic mild stress can lead to vascular endothelial dysfunction in rats. |
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| Keywords: | chronic mild stress rat vascular endothelial |
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