首发精神分裂症患者血清同型半胱氨酸水平与认知功能的关系

目的：探讨首发精神分裂症患者血清同型半胱氨酸（ Hcy ）水平与认知功能的关系。方法采用丹迪Keypoint 四通道诱发电位仪对84例首发精神分裂症患者（研究组）进行事件相关电位（ERP）检测，用高效液相色谱法检测血清Hcy水平，并将检测结果与76例正常健康者（对照组）进行比较。采用阳性和阴性症状量表（PANSS）评定患者的临床症状，并分析其与血清Hcy水平和ERP的相关性。结果与对照组比较，研究组患者血清 Hcy水平明显增高，差异有统计学意义（P ＜0.01）；ERP测定中N2波潜伏期（PL ）、P3 PL明显延长，P3波幅（amp）明显降低，差异均有统计学意义（P ＜0.01）；相关分析显示，研究组患者血清 Hcy水平与ERP测定中的N2 PL、P3 PL及PANSS评分呈正相关（r ＝0．35、0．38、0．46，P ＜0.01），与ERP测定成分中的N1 PL、P2 PL无相关性（r ＝-0．19∽02．4，P ＞0.05），与P3 amp呈负相关（r ＝-0．38，P ＜0.01）。结论首发精神分裂症患者存在一定程度的高 Hcy血症和认知功能损害，且高Hcy与认知功能障碍有一定的相关性。

Relationship between the level of serum homocysteine and cognitive function in patients with first-episode schizophrenia

Objective To explore the relationship between serum homocysteine （Hcy ） and cognitive function in patients with first-episode schizophrenia .Methods ERP and level of serum Hcy of 84 cases with first-episode schizophrenia were detected by Dandy Keypoint four-channel trigger potentiometer and high-performance liquid chromatography respectively .Results were compared with 76 healthy cases . Clinical symptoms of patients were evaluated by PANSS ,and their correlations with ERP and level of ser-um Hcy were analyzed .Results Compared with the healthy cases ,the level of serum Hcy in patients in-creased significantly ,and the difference was statistically significant （P 〈0.01） .In ERP detection ,N2 PL and P3 PL prolonged obviously while P3 amp decreased obviously ,the differences were statistically signifi-cant （P 〈0.01） .The level of serum Hcy ,N2 PL ,N3 PL in ERP detection and PANSS had positive correla-tion （r=0 .35 ,0. 38 ,0. 46 ,P 〈0.01） ,and had no correlation with N1 PL and P2 PL while had negative cor-relation with P3 amp （r = -0 3.8 ,P 〈0.01） .Conclusion There exist high level of serum Hcy and cogni-tive impairment in patients with first -episode schizophrenia .