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| ATP结合盒转运蛋白A1与动脉粥样硬化 | |
| 引用本文： | 苟连平,吕湛,秦俭. ATP结合盒转运蛋白A1与动脉粥样硬化[J]. 心血管病学进展, 2007, 28(6): 951-954 |
| 作者姓名： | 苟连平 吕湛 秦俭 |
| 作者单位： | 1. 重庆医科大学附属第一医院心内科,重庆,400010;川北医学院附属医院心内科,四川,南充,637000 2. 川北医学院附属医院心内科,四川,南充,637000 3. 重庆医科大学附属第一医院心内科,重庆,400010 |
| 摘 要： | 对Tangier病病因的研究,发现ATP结合盒转运蛋白A1(ATP binding cassette transport protein A1,ABCA1)在胆固醇逆向转运(reverse cholesterol transport,RCT)中起重要作用。ABCA1主要通过核受体PPARs途径发挥作用。ABCA1基因变异影响其功能。 |
| 关 键 词： | ATP结合盒转运蛋白A1 核受体 胆固醇逆向转运 ABCA1基因 变异(遗传学) |
| 文章编号： | 1004-3934（2007）06-0951-04 |
| 修稿时间： | 2006-11-06 |
Progress in ABCA1 and Atherosclerosis |
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| GOU Lian-ping,LU Zhan,QIN Jian. Progress in ABCA1 and Atherosclerosis[J]. Advances in Cardiovascular Diseases, 2007, 28(6): 951-954 | |
| Authors: | GOU Lian-ping LU Zhan QIN Jian |
| Affiliation: | 1. Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China ; 2. Department of Cardiology, The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China |
| Abstract: | During a study of the cause of Tangier disease it was discovered that ATP binding cassette transport protein A1 (ABCA1) plays a key role in reverse cholesterol transport (RCT). ABCA1 performs a function in nuclear receptor PPAR pathway. The function of ABCA1 is influenced by the varieties of gene ABCA1. |
| Keywords: | ABCA1 nuclear recepter RCT gene ABCA1 variety(heredity) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |