| FKBP12.6与RyR2的关系及其在心脏疾病中的意义 |
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| 引用本文： | 王逵,杨成明.FKBP12.6与RyR2的关系及其在心脏疾病中的意义[J].心血管病学进展,2007,28(6):979-982. |
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| 作者姓名： | 王逵 杨成明 |
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| 作者单位： | 重庆第三军医大学大坪医院野战外科研究所心内科,重庆,400042 |
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| 摘 要： | FKBP12.6从RyR2解离导致通道构象及功能改变。Ca2 从SR漏出使SR的Ca2 负荷减少,Ca2 瞬变减少,舒缩时RyR2耦联障碍,最终引起心肌功能异常。而且RyR2对CICR敏感性提高导致心肌迟后去极诱发心律失常。通过过表达或增加FKBP12.6对RyR2亲和力可以改善通道缺陷,从而使心脏功能及心律失常得到改善。
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| 关 键 词： | 心力衰竭 运动性心律失常 |
| 文章编号： | 1004-3934（2007）06-0979-04 |
| 修稿时间： | 2007-02-28 |
The Relationship of FKBP12.6 and RyR2 and Its Significance in Heart Diseases |
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| WANG Kui,YANG Cheng-ming.The Relationship of FKBP12.6 and RyR2 and Its Significance in Heart Diseases[J].Advances in Cardiovascular Diseases,2007,28(6):979-982. |
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| Authors: | WANG Kui YANG Cheng-ming |
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| Institution: | Department of Cardiology, Institute of Surgery Research, Daping Hospital Affiliated to The Third Military Medical University, Chongqing 400042, China |
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| Abstract: | The dissociation of FKBP12.6 from RyR2 in SR of cardiac myocytes causes conformational and functional changes of the channel and an abnormal Ca2 leak from SR during diastole. These changes decrease Ca2 load in SR, Ca2 transient during systole and uncouples multiple RyR2s, which subsequently lead to dysfunction of systole and diastole. The increase of RyR2 sensitivity to CICR results is delayed after depolarization and triggers fatal ventricular arrhythmia and sudden death. By overexpressing FKBP12.6 or enhancing the affinity of FKBP12.6 to RyR2, it can correct the defect of RyR2 and thus improve cardiac function and prevent from arrhythmia. Therefore the restoration of normal association between FKBP12.6 and RyR2 can served as a new focus of therapy. |
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| Keywords: | FKBP12 6 RyR2 |
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