Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma: A preliminary retrospective study of French experience |
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Authors: | Nicolas Leboulanger,Pierre Fayoux,Amanda Cox,Laure Carrabin,Richard Nicollas,Sonia Ayari,Emmanuel Lescanne,Thierry Mom,Jean-Paul Marie,Eré a-Noë l Garabé dian |
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Affiliation: | a Hôpital Armand-Trousseau, 75012 Paris, France b Hôpital Jeanne de Flandre, 59037 Lille, France c Hôpital Robert Debré, 75020 Paris, France d Hôpital Necker, 75015 Paris, France e Hôpital de la Timone, 13385 Marseille, France f Hôpital Edouard Herriot, 69437 Lyon, France g Hôpital Clocheville, 37044 Tours, France h Hôpital Morvan, 29609 Brest, France i Hôpital Gabriel Montpied, 63003 Clermont Ferrand, France j Hôpital Guy de Chauliac, 34000 Montpellier, France k Hôpital Charles Nicolle, 76000 Rouen, France |
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Abstract: | ObjectivePreliminary assessment of the efficacy of propranolol on subglottic hemangioma in children on a nation-wide scale.MethodsMulticentric, retrospective study of clinical files of 14 children; pre- and post-treatment endoscopies.ResultsMean age at diagnosis was 2.3 (0.7-4) months. Mean percentage of airway obstruction was 68% (15-90) before propranolol introduction. Propranolol was started at 5.2 (0.7-16) months of age. This treatment was effective in all cases with a mean regression of the stenosis to 22% after 2 weeks and 12% after 4 weeks. Other medical treatments (steroids) could be stopped. In one patient, a side effect of propranolol motivated the switch to another β-blocker. In four patients, treatment was stopped after 5.2 (1-10) months with a relapse in 2 (50%) cases. One of these two patients developed a resistance to propranolol and required a surgical procedure by external approach.ConclusionThis preliminary nation-wide survey confirms propranolol high effectiveness against airways’ localization of infantile hemangiomas. Propranolol also allows alleviation or cut-off of previous medical treatments. However, recurrences are possible after early treatment interruption. |
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Keywords: | IH, infantile hemangioma GERD, gastro-esophageal reflux disease |
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