The V109G polymorphism in the p27 gene is associated with endometriosis |
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Authors: | Cíntia M Camargo-Kosugi Ismael DCG da Silva Hélio SatoPaulo D’Amora Cristina V CarvalhoNaiara C Nogueira-de-Souza Manoel JCB GirãoEduardo Schor |
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Institution: | Federal University of São Paulo/Escola Paulista de Medicina, Gynecology Department, Pelvic Pain and Endometriosis Unit, 04039-032 Sao Paulo, SP, Brazil |
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Abstract: | ObjectiveTo investigate the prevalence of the p27 gene polymorphism in women with endometriosis.Study designTransversal case–control study. Genomic DNA was extracted from cells collected from buccal swabs. The p27 V109G polymorphism was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Brazilian population.ResultsWe analysed the 104 patients and 109 control subjects. The distribution of genotype and allele frequencies of p27 V109G polymorphism was significantly different between the endometriosis cases and healthy women (p = 0.016 and 0.002). Women who had at least one mutated allele presented twofold chances for endometriosis development (OR = 1.9; 95% CI, 1.120–3.343).ConclusionThe polymorphic variant at codon 109 of the p27 gene seems to be associated with higher risk of endometriosis development. |
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Keywords: | Polymorphism Endometriosis p27 |
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