癌胚抗原和C-反应蛋白联合检测在良恶性胸腔积液鉴别诊断中的意义

目的探讨肿瘤标记物癌胚抗原(CEA)和C反-应蛋白(CRP)联合检测在良、恶性胸腔积液鉴别诊断中的临床意义。方法采用免疫放射法分别检测23例恶性胸腔积液(恶性组)和35例良性胸腔积液患者(良性组)胸水样本中CEA含量和CRP水平,并进行对比分析。结果恶性组患者胸水样本中CEA含量明显高于良性组(P<0.05),CRP水平明显低于良性组,差异有统计学意义(P<0.001),采用胸水中CEA含量及CRP联合检测诊断良、恶性胸腔积液的灵敏度、特异性和准确率分别为65.7%、70%和67.2%。结论联合检测胸腔积液中CEA和CRP水平在良、恶性胸腔积液鉴别诊断中具有重要的临床价值。

Combined detetion of carcinoembryonic antigen and C-reactive protein in identifying benign and malignant pleural effusion

Objective To explore the clinical significance of carcinoembryonic antigen(CEA) and C-reactive protein(CRP) combined detection in identifying benign and malignant pleural effusion.Methods The CEA and CRP level in pleural effusion of 23 cases of patients with malignant pleural effusion(malignant group) and 35 cases of patients with benign pleural effusion(benign group) was detected with direct radioimmunoassay.Results The CEA level in pleural effusion of patients in malignant group was higher than that in benign group(P< 0.05),while the CRP level was lower than that in benign group(P<0.001).The sensitivity,specificity and veracity of CEA and CRP combined detection in diagnosing malignant and benign plural effusion were 65.7%,70% and 67.2% respectively.Conclusion Combined dection of CEA and CRP in pleural effusion may have significant clinical value in identifying benign and malignant pleural effusion.