热毒宁注射液治疗儿童支气管肺炎的临床观察

目的：比较选择儿童支气管肺炎的优化治疗方案。方法：将300例支气管肺炎患儿以随机抽样法分为5组,每组60例,在常规化痰平喘对症治疗基础上分别给予头孢呋辛、头孢曲松、热毒宁注射液、热毒宁注射液＋头孢呋辛、热毒宁注射液＋头孢曲松。每日观察患儿发热、咳嗽及肺部罗音恢复情况,对治疗前后症状体征变化进行对比,并对发热、咳嗽进行评分。治疗结束后复查胸部X线片,观察胸部X线片恢复情况。同时进行血、尿、便常规及肝、肾功能的检查,观察不良反应事件。结果：5组患儿治疗后症状平均积分均显著低于治疗前（P〈0.01）,联合热毒宁注射液组患儿临床症状积分改善优于单用抗菌药物治疗组（P〈0.05）。热毒宁注射液＋头孢呋辛组、热毒宁注射液＋头孢曲松组比较,2组疗效、治疗后症状持续时间、平均积分方面的差异无统计学意义（P〉0.05）,但均显著高于单用头孢曲松及头孢呋辛组;单用热毒宁注射液组与单用头孢呋辛组总有效率比较,差异无统计学意义（P〉0.05）。住院费用方面,联合用药组比单药组用药费用低,差异均有统计学意义（P〈0.01）;而热毒宁注射液＋头孢呋辛组的住院费用显著低于热毒宁注射液＋头孢曲松组,差异有统计学意义（P〈0.05）。5组患儿均未见明显的肝、肾不良反应。结论：热毒宁注射液能提高小儿支气管肺炎的疗效,快速缓解症状;热毒宁注射液＋头孢呋辛是治疗小儿支气管肺炎安全、有效、经济的方案。

Clinical Efficacy of Reduning Injection for Bronchopneumonia in Children

OBJECTIVE ：To optimize the therapeutic schedule for bronchopneumonia in children. METHODS： A total of 300 children with bronchopneumonia were randomized to 5 groups of 60 cases each to be treated with cefuroxime, ceftriaxone, Reduning injection, Reduning injection plus cefuroxime, or Reduning injection plus eeftriaxone. The patients were followed daily for symptoms and signs recovery such as fever, cough and rales of lungs and the integral for fever and cough were recorded. Chest x-ray film was taken after treatment meanwhile routine blood, urine and stool test for as well as hepatorenal function tests were performed and adverse events were observed. RESULTS ： The average integral of symptoms in all of the 5 groups were significantly lower after treatment than before treatment （P 〈0. 01 ）, and the patients treated with antibiotics plus Reduning showed better improvement in average integral of symptoms than in those treated with antibiotics alone （ P 〈 0. 05 ）. The patients treated with Reduning injection plus eefuroxime and those with Reduning injection plus ceflriaxone showed no statistical significant differences with regard to curative efficacy, duration of symptoms and average integral of symptoms （P 〉 0. 05 ）, yet the patients treated by the two combination therapies showed significantly higher response rate than in those treated with either ceftriaxone or cefuroxime; however, the differences in total response rate were not statistically significant between those treated with ceftriaxone and those with cefuroxime （P 〉 0. 05 ）. The hospitalization cost in those treated with Reduning injection plus cefuroxime or Reduning injection ptus ceftriaxone were lower than in those treated with ceftriaxone or cefuroxime （P 〈0.01 ）, which was significantly lower in those treated with Reduning plus cefuroxime than in those treated with Reduning injection plus ceftriaxone （ P 〈 0.05 ）. 5 groups. CONCLUSION： Treatment of bronchopneumonia in curative efficacy and rapid relief of symptoms. Reduning plus bronchopneumonia in children. Hepatorenal adverse drug reactions were unnoted in children with Reduning injection resulted in improved cefuroxime is safe, effective and economic therapy for