吉林大学白求恩第一医院美罗培南临床应用分析

目的：了解我院抗菌药物美罗培南的应用现况,促进美罗培南在临床中的合理应用,减轻患者经济负担和降低细菌耐药率。方法：抽查2012年1—6月我院使用美罗培南的住院患者病历,每月以随机抽样法抽取50份,共300份病历,对其进行调查分析,并根据相关标准进行专项点评。结果：抽查的病例中,使用美罗培南的住院患者数排序居前3位的科室分别为肿瘤中心、神经外科与感染科;抽查的300例住院患者中有234例进行了细菌培养,送检率为78%;使用美罗培南治疗的患者有效率为82.7%（248/300）。我院美罗培南合理用药率为77%（231/300）。结论：从调查结果中发现,多数患者用药较为合理,同时也存在着多种不合理用药现象,主要表现为无指征用药、用法与用量不合理、联合用药不合理等,合理用药水平有待进一步提高。

Utilization Analysis of Clinical Application of Meropenem in Bethune First Hospital of Jilin University

OBJECTIVE： To investigate the application status of meropenem （antibacterial agent） in our hospital and to promote its use in clinic, relieve patients＇ economic burden and lower the antibiotic resistance rate. METHODS： A total of 300 medical records of the inpatients treated with meropenem sampled in our hospital during Jan.-Jun. period of 2012 （50 cases monthly） were reviewed and given special comments in accordance with the related criteria. RESULTS： The reviewing of the cases showed that the top 3 departments ranked by the number of patients using meropenem included cancer center, neurosurgery department and department of infectious diseases. Of the 300 inpatient cases reviewed, bacterial culture was performed in 234 （78%）. The effective rate for the meropenem-treated patients was as high as 82.7% （248/300）. The rate of rational administration of meropenem was 77% （231/300）. CONCLUSION： From the findings we can see that the drug use in most of the patients was rational, yet there were still many irrational phenomena that manifested as non-indication drug use, improper dosage and administration or irrational drug combination etc. The level of rational use of drugs remains to be improved further.