Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro |
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| Authors: | Hannelore I Bax Irma A J M Bakker-Woudenberg Marian T ten Kate Annelies Verbon Jurriaan E M de Steenwinkel |
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| Institution: | aDepartment of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands;bDepartment of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands |
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| Abstract: | The in vitro activities of clarithromycin and tigecycline alone and in combination against Mycobacterium avium were assessed. The activity of clarithromycin was time dependent, highly variable, and often resulted in clarithromycin resistance. Tigecycline showed concentration-dependent activity, and mycobacterial killing could only be achieved at high concentrations. Tigecycline enhanced clarithromycin activity against M. avium and prevented clarithromycin resistance. Whether there is clinical usefulness of tigecycline in the treatment of M. avium infections needs further study. |
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