| 毛冬青甲素对大鼠急性缺氧性肺血管收缩反应的影响及其机制 |
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| 引用本文： | 徐霆,金咸瑢,王迪浔. 毛冬青甲素对大鼠急性缺氧性肺血管收缩反应的影响及其机制[J]. 中国病理生理杂志, 1992, 0(1) |
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| 作者姓名： | 徐霆 金咸瑢 王迪浔 |
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| 作者单位： | 同济医科大学病理生理教研室，同济医科大学病理生理教研室，同济医科大学病理生理教研室 军事医学科学院六所 |
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| 基金项目： | “七·五”国家攻关课题资助 |
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| 摘 要： | 急性缺氧性肺血管收缩反应(HPV)具有重要的生理意义,前列腺素(PGs)和白三烯(LTs)参与了HPV的发生。本实验研究了中药成分毛冬青甲素对HPV的影响及其作用与PGs和LTs的关系。结果表明毛冬青甲素可增加基础肺血管阻力,减少心输出量,其作用一部分是通过增加LTs生成所致,而与PGs无明显关系。毛冬青甲素可增强HPV,其作用一方面是通过抑制Wistar大鼠缺氧时以舒血管性PGs(尤其是PGI_2)为主的PGs的产生,另一方面是通过增加LTs生成所致,也可能有其它机制参与。
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| 关 键 词： | 缺氧症 血管收缩 前列腺素 白三烯 |
Effects of Ilexonin A on acute hypoxic pulmonary vasoconstriction in rats |
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| Xu Ting,Jin Xian-Rong,et al. Effects of Ilexonin A on acute hypoxic pulmonary vasoconstriction in rats[J]. Chinese Journal of Pathophysiology, 1992, 0(1) |
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| Authors: | Xu Ting Jin Xian-Rong et al |
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| Affiliation: | Xu Ting,Jin Xian-Rong,et al Department of Pathophysiology,Tongji Medical University,Wuhan |
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| Abstract: | Acute hypoxic pulmonary vasoconstriction (HPV) plays an important role in physiological regulation. The purpose of this study was to explore the effects of Ilexonin A on hemodynamics and HPV, and their relation to prostaglandins (PG_(?)) and leukotrienes (LT_(?)).The results show that the high pulmonary vascular resistance induced by Ilexonin A in normoxic rats may be partially caused by the increased LTs and have no relation to PGs. Ilexonin A may potentiate HPV at least by two ways: replacing the production of PGs (especially PGI_2) in hypoxic Wistar rats, and increasing LTs production. |
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| Keywords: | Anoxia Vasoconstriction Prostaglandins Leukotrienes |
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