阿司匹林抵抗的实验室检测研究进展

阿司匹林抵抗是指患者规律服用常规剂量的阿司匹林仍不能减少临床动脉血栓栓塞性缺血事件的发生。目前,用于检测阿司匹林抵抗的实验室方法主要包括检测血栓素A2的生成和依赖于血栓素的血小板功能,且研究表明,阿司匹林抵抗的实验室检测结果与心血管事件的危险性增高呈独立相关。然而,目前实验室诊断阿司匹林抵抗尚无统一的标准。现就近年来有关阿司匹林抵抗的实验室检测研究进展作一综述。

Progress of Research into Laboratory Tests for Aspirin Resistance

Aspirin resistance is defined as the failure of aspirin to prevent clinical atherothromboembolic ischaemic events in patients prescribed aspirin.Aspirin resistance can be detected by laboratory tests of platelet thromboxane production,or platelet function that depend on platelet thromboxane A2 production.It has been demonstrated that the results of laboratory tests are independently associated with the risk of cardiovascular events.However,there is currently no standardized approach to the diagnosis.This article provides a brief review of the progress of research into laboratory tests for aspirin resistance.