沙利度胺联合复方氟米松软膏治疗结节性痒疹疗效观察

目的观察沙利度胺联合复方氟米松软膏治疗结节性痒疹疗效。方法将87例结节性痒疹患者随机分为两组。治疗组45例,口服沙利度胺50mg,2次/d,症状改善后逐步减量50mg或25mg,1次/d维持,联合外用复方氟米松软膏,1次/d,共8周;对照组42例,口服左西替利嗪片5mg,1次/d,联合外用复方氟米松软膏1次/d,共8周。结果治疗组有效率为91.11%,对照组为69.05%,两组有效率差异有统计学意义（P〈0.05）,均无明显不良反应。结论沙利度胺联合复方氟米松软膏治疗结节性痒疹安全可靠。

Efficacy Observation of Thalidomide Combined Flumetasone Ointment in the Treatment of Prurigo Nodularis

Objective To observe the clinical efficacy of combination of thalidomide and flumetasone ointment in the treatment of prurigo nodularis. Methods Eighty-seven patients were randomly divided into two groups. 45 pa- tients in the treatment group were treated with thalidomide and flumetasone ointment for 8 weeks. Initial dose of thalido- mide is 50rag twice a day, and the dose is reduced to 50rag or 25rag once a day when symptoms are improved gradually. Flumetasone ointment is administrated once a day. Forty-two patients in the control group were treated with levoeetirizine and flumetasone ointment for 8 weeks. The dose of is levocetirizine 5mg once a day, and flumetasone ointment is admin- istrated once a day. Results After 8 weeks, the effective rates of treatment group was 91.11%, and the control group was 69.05 %. There was statistical significance between the two groups （P 〈 0. 05 ）. Conclusion It was safe and relia- ble to treat prurigo nodularis with combination of thalidomide and flumetasone ointment.