| T3对体外培养的大鼠胚胎大脑神经细胞神经递质代谢的影响 |
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| 引用本文： | 孟群 阮启志. T3对体外培养的大鼠胚胎大脑神经细胞神经递质代谢的影响[J]. 中国地方病学杂志, 1992, 11(1): 18-20,66 |
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| 作者姓名： | 孟群 阮启志 |
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| 作者单位： | 锦州医学院(孟群，阮启志，张尤新)，锦州医学院(张曼) |
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| 摘 要： | 本文采用无血清培养液(SFM),加入生理浓度的 T_3,观察 T_3对15—18天大鼠胚胎大脑神经细胞神经递质代谢的影响。发现 T_3能明显促进体外培养的胎鼠大脑神经细胞合成,分泌单胺类神经递质,促进神经细胞发育成熟。
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| 关 键 词： | 克汀病 SFM 大脑神经细胞 |
Effects of T_3 on the neurotransmitter metabolism of neurons from rat fetal cerebra in vitro |
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| Meng Qun et al. Effects of T_3 on the neurotransmitter metabolism of neurons from rat fetal cerebra in vitro[J]. Chinese Jouranl of Endemiology, 1992, 11(1): 18-20,66 |
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| Authors: | Meng Qun et al |
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| Abstract: | In order to study the effects of T_3 on the neurotransmitter metablism ofcerebral neurons from rat embryos in vitro,we used rat cerebral neurons from15 to 18 day embryos for primary monolayer culture in vitro.The changes of neurotransmitters 5-HT,5-HIAA,NE,and DA were assayed.The results obtained suggested (1) T_3 may enhance the metablism of ratfetal cerebral neurons,but it is not the only factor;(2)SEM makesselected neurons grow,and inhibits non-neurons and (3) it is a good methodto study the growth,differentiation and functions of neurons.This paperwill be helpful to the further study of pathogenisis of endemic cretinism. |
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| Keywords: | Triiodothyronine Brain nervous cell Neurotransmitters Cell culture |
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