莫沙必利在老年患者肠镜检查前肠道准备中的价值研究

目的：探讨莫沙必利与复方聚乙二醇电解质散联用与单用复方聚乙二醇电解质散对老年患者进行结肠镜检查的肠道准备清肠效果比较。方法：将164例拟行结肠镜检查的老年患者随机分成A、B、C三组，A组结肠镜检查前服用聚乙二醇2L，B组结肠镜检查前6．5h服用10mg莫沙必利，聚乙二醇服用方法同A组，C组结肠镜检查前6d开始服用莫沙必利5mgtidAc，肠镜检查当天肠道准备同B组。分别记录首次大便时间、大便次数、有无不良反应、清肠效果等情况。结果：C组和B组首次排便时间短于A组，差异有统计学意义（P〈0．05），C、B两组间首次排便时间比较无统计学差异（P〉0．05）。C组排便次数大于A组和B组，差异有统计学意义（P〈0．05），A、B两组间排便次数比较无统计学差异（P〉0．05）。C组患者各部分肠道及总体肠道清洁效果均优于A、B两组，差异有统计学意义（P〈0．05），A、B两组间总体肠道清洁度效果比较无统计学差异（P〉0．05）。结论：对老年患者进行结肠镜检查肠道准备，联用莫沙必利与聚乙二醇电解质散1周相比单用聚乙二醇电解质散和加用顿服莫沙必利，可以增加排便次数，并能提高患者肠道准备效果。

Research on the value of Mosapride in bowel preparation before colonoscopy in elderly patients

AIM： To investigate the efficacy of oral administration of polyethylene glycolelectrolyte powder combined with mosapride in bowel preparation before colonoscopy in elderly patients. METHODS： One hundred and sixtyfour patients undergoing colonoscopy examina- tion were randomly divided into A, B and C three groups. Before colonoscopy examination, the patient took orally polyethylene glycol-elec- trolyte powder 2 L in group A , besides method as mentioned above, while the patients in group B took mosapride 10 mg 6.5 hour ago. Besides method as mentioned in group B, the patients in group C took mosapride 5 mg three times a day for 6 days before colonoscopy examination. Then, the time of the first stool, stool frequency, adverse reactions of the patients as well as the quality of the bowel cleanness and so on were recorded and compared. RESULTS： The time of the first stool in group B and C showed earlier than group A with statistical significance （P〈 0. 05） ,but this was no difference between group B and group C（P〈0.05）. Compared with the group A and group B, the stool frequency was significantly increased in the group C （P 0.05）, but this was no difference between group A and group B（P〈0.05）. The group C showed apositive efficacy on the quality of the bowel cleanness （P 〈 0.05）, whereas this was no difference between group A and group B （P 0.05）. CONCLUSION： Compared with singleuse polyethylene glycol electrolyte powder and combined with mosapride one time, oral administration of polyethylene glycol-electrolyte powder combined with mosapride for one week before colonoscopy can increase the stool frequency and the quality of the bowel cleanness in elderly patients.