早期持续性肾脏替代治疗对脓毒症患者的疗效观察

目的:观察早期持续性肾脏替代治疗(CRRT)对脓毒症患者的疗效。方法:脓毒症患者47例,随机分为对照组23例,治疗组24例,分别于治疗前及治疗后12 h、48 h监测患者心率(HR)、平均动脉压(MAP),同时测定动脉血气氧分压(PO2)、乳酸(Lac)、计算氧合指数(OI,PaO2/FiO2)。并采用APACHE-Ⅱ评分对患者整体病情进行评价,同时观察ICU住院时间及28 d死亡率。结果:与对照组相比,治疗组患者APACHEⅡ评分减少,氧合指数及血流动力学指标好转,28 d死亡率降低,ICU住院时间缩短,差异均有统计学意义(P<0.05)。结论:早期持续性肾脏替代治疗对多个器官起支持作用,能有效改善血流动力学指标,改善预后。

Clinical Observation on Sepsis Patients with Early Continuous renal replacement therapy

Objective To observe early continuous renal replacement therapy （CRRT） curative effect in patients with sepsis.Method 47 patients with sepsis,23 cases were randomly divided into control group and treatment group 24 cases,respectively,before treatment and 12 h,48 h after treatment monitoring patients＇ heart rate （HR）,mean arterial pressure （MAP）,and determination of arterial blood gas oxygen partial pressure （PO2）,lactic acid （Lac）,calculating oxygenation index （OI,PaO2 / FiO2）.And USES the APACHE - Ⅱ score to evaluate the overall patient,28 d at the same time observe the ICU length of hospital stay,and mortality.Results Compared with control group,treatment group patients with APACHE Ⅱ score decreased,oxygenation index and hemodynamic index,28 d mortality,ICU hospitalization time,the difference had statistical significance （P〈0.05）.Conclusion Early continuous renal replacement therapy for multiple organ support role,can effectively improve hemodynamic index,improve the prognosis.