胎膜早破胎膜中白细胞介素18的表达及其临床意义

目的]探讨白细胞介素18(interleukin - 18,IL - 18)作为诊断胎膜早破(premature rupture of membrane,PROM)生物学标志的可能性.方法]应用免疫组织化学SP法检测42例PROM患者及28例正常产孕妇胎膜的IL - 18表达,并加以比较.结果]PROM胎膜中IL- 18表达明显高于正常胎膜组织(P＜0.05).合并亚临床绒毛膜羊膜炎PROM胎膜组织的IL - 18表达明显高于不合并绒毛膜羊膜炎组织(P＜0.05).IL - 18的表达与胎膜早破时间无明显相关性.结论] IL-18作为一种细胞因子有可能成为PROM的预测性指标.

Expression and clinical significance of interleukin-18 in premature rupture of membrane

Objective] To detect expresson of interleukin-18(IL-18) in the tissne with premature rupture of fetal membrane(PROM) and clinical pathological significance of the expression.Methods] The expression of IL-18 was detected in 42 tissues with premature rupture of fetal membranes and 28 normal of fetal membrane tissues without by immunohistochemistry.Results] The expression of IL-18 was significantly higher in premature rupture of membrane than that in normal(P<0.05),and the expression of the tissues in PROM with sub-clinical chorioamonitis was significantly higher than that without(P<0.05).The correlativity between the expression of IL-8 and the time of PROM was not clear(P>0.05).Conclusions] The IL-18 could become a predictable index of PROM.