Epidermolysis bullosa acquisita associated with chronic lymphatic leukaemia |
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| Authors: | MARCIA SHAW,P.H. McKEE,&dagger ,ELIZABETH GAMINARA&Dagger ,T.C. PEARSON&Dagger ,BERYL EVANS&dagger ,D.H. McGIBBON |
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| Affiliation: | Department of Dermatology, St. Thomas' Hospital, London, UK;Department of Histopathology, St. Thomas' Hospital Medical School, London, UK;Department of Haematology, St. Thomas' Hospital Medical School, London, UK |
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| Abstract: | A 61–year-old man developed epidermolysis bullosa acquisita (EBA) in association with an IgM paraprotein and chronic lymphatic leukaemia (CLL). Direct immunocyto-chemistry and immunoelectron microscopy confirmed the presence of IgM at the dermoepidermal junction. IgG was not present. This appears to be a unique observation in EBA and is discussed in relationship to the possible pathogenesis of the disorder. |
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