Assistant radiotherapeutic effect of Jiaqi Mixture on tumor-bearing mice

Objective

The aim was to study the assistant radiotherapeutic effect of Jiaqi Mixture (JQM) on Ehrlich’s ascites carcinoma (EAC) mice.

Methods

The EAC-cancer model was made up with Kunming mice. The tumor-bearing mice were treated with whole body exposure (8 Gy) and intragastric administration of JQM, and the changes of tumor weight, the total number of white blood cells (WBC) and immune system were observed.

Results

The average tumor weight, WBC, spleen coefficient, the stimulation index (SI) of Con A and LPS and the natural killing (NK) cell activity of mice decreased in some degree after radiotherapy, but the average tumor weight decreased more obviously in radiotherapy + medicine groups (compared with tumor control group, P < 0.05); and the other above indexes were much higher in radiotherapy + medicine groups than those in radiotherapy groups (P < 0.05?0.01).

Conclusion

It was suggested that JQM can enhance the effect of radiation therapy and protect the normal immune system caused by radiation therapy.