| 大鼠肝纤维化过程中肝组织及血清中粗纤维调节素的动态变化研究 |
| |
| 引用本文： | 姚定康,李石,孔宪涛,叶廷军. 大鼠肝纤维化过程中肝组织及血清中粗纤维调节素的动态变化研究[J]. 中国病理生理杂志, 2002, 18(1): 62-63 |
| |
| 作者姓名： | 姚定康 李石 孔宪涛 叶廷军 |
| |
| 作者单位： | 第二军医大学附属长征医院，上海 200003 |
| |
| 摘 要： | 目的：观察粗纤维调节素（Un）在大鼠肝纤维化肝组织及血清中的动态变化，探讨其在正常和纤维化大鼠肝组织中的表达及其血清学检测的价值。方法：以CCl4诱发大鼠肝纤维化模型，采用ABC免疫组化方法检测肝组织中Un分布，用ELISA方法检测血清中Un的含量。结果：随着CCl4造模时间的延长，Un在肝组织中沉积增加，主要在汇管区、中央静脉壁及纤维间隔内分布。血清Un含量也随肝纤维化的加重而升高。结论：Un是肝组织中一种重要的细胞外基质成分，在肝纤维化过程中表达增加；血清Un可以作为反映肝纤维化的一种血清学指标。
|
| 关 键 词： | 肝硬化 四氯化碳 大鼠 |
| 文章编号： | 1000-4718(2002)01-0062-02 |
| 收稿时间： | 2000-08-14 |
Expression of undulin in experimental rat liver fibrosis |
| |
| YAO Ding-kang,LI Shi,KONG Xian-tao,YE Ting-jun. Expression of undulin in experimental rat liver fibrosis[J]. Chinese Journal of Pathophysiology, 2002, 18(1): 62-63 |
| |
| Authors: | YAO Ding-kang LI Shi KONG Xian-tao YE Ting-jun |
| |
| Affiliation: | Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China |
| |
| Abstract: | AIM: To observe the expression of undulin(Un) in liver tissue and to clarify the diagnostic significance of serum Un in experimental rat liver fibrosis. METHODS: Rat liver fibrosis was induced by carbon tetrachloride. The expression of Un in liver tissue was detected by immunohistochemical method. Serum Un levels was measured by enzyme immunoassay.RESULTS: Expression of Un increased in fibrotic liver than normal liver, and it was mainly distributed in portal tract stroma, central veins and fibrotic septa in fibrotic liver. Also, the level of serum Un was significantly higher in fibrotic liver than normal liver.CONCLUSION: These data suggest that Un should be a component of the hepatic extracellar matrix, and its expression could be increased greatly in fibrotic rat liver. Serum Un levels may be used as an indicator in liver fibrosis diagnosis. |
| |
| Keywords: | Liver cirrhosis Carbon tetrachloride Rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国病理生理杂志》浏览原始摘要信息 |
|
点击此处可从《中国病理生理杂志》下载免费的PDF全文 |
