前列清颗粒对大鼠慢性非细菌性前列腺炎的作用

目的 评价前列清颗粒对慢性非细菌性前列腺炎模型大鼠的治疗作用.方法 采用消痔灵致慢性非细菌性前列腺炎大鼠模型,设前列清颗粒高、中、低剂量组以及前列泰胶囊对照组、模型组和空白对照组,灌胃给药,共45 d.给药后检测全血和前列腺液中自细胞数、前列腺液中卵磷脂小体密度,并对前列腺组织进行病理学观察.结果 与模型组比较,前列清三个剂量组前列腺液中白细胞数及前列腺指数均明显降低(P＜ 0.05,P＜0.01)；前列清中、高剂量组全血中白细胞数明显降低,大鼠卵磷脂小体密度明显升高,前列腺的病理改变明显减轻(P＜ 0.05,P＜0.01).结论 前列清颗粒对模型大鼠慢性非细菌性前列腺炎有明显治疗作用.

Effects of Qianlieqing Granule on Chronic Abacterial Prostatitis in Rats

Objective To evaluate the therapeutic effects of Qianlieqing Granule(QG) on rat models of chronic abacterial prostatitis(CAP).Methods The rat models of CAP were established by injection of Xiaozhiling.The rats were divided into six groups:model group,blank control group,high-,moderate-and low-dosage QG groups and Qianlietai Capsule(QC) group.The rats were given gastric gavage of corresponding drugs for 45 days according to the experimental design.After treatment,white blood cell(WBC) count in whole blood and prostatic fluid,and lecithin corpuscle density in prostatic fluid were examined.Moreover,the pathological changes of prostate tissues were observed.Results The number of WBC in prostatic fluid and prostatic index of QG groups were significantly lower than those in the model group(P < 0.05 or P < 0.01).Moderate-and high-dosage QG significantly lowered the number of WBC in whole blood,increased the density of lecithin corpuscle,and relieved the pathological changes of rat prostatic tissues(P < 0.05 or P < 0.01).Conclusion QG has significant therapeutic effects on CAP in rat models.