| 复方贞术调脂胶囊对MS大鼠胰岛素抵抗及胰岛素信号PI-3K的影响 |
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| 引用本文： | 胡旭光,郭姣,贝伟剑,何伟,王槾,刘沙沙.复方贞术调脂胶囊对MS大鼠胰岛素抵抗及胰岛素信号PI-3K的影响[J].中药新药与临床药理,2012,23(2):140-143. |
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| 作者姓名： | 胡旭光 郭姣 贝伟剑 何伟 王槾 刘沙沙 |
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| 作者单位： | 1. 国家中医药管理局高脂血症“调肝降脂”重点研究室,广东药学院,广州510006
2. 国家中医药管理局高脂血症“调肝降脂”重点研究室,国家中医药管理局“脂代谢”三级实验室,广东省代谢性疾病中医药防治重点实验室,广州中医药大学,广州510006 |
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| 基金项目： | 国家自然科学基金项目,广东省自然科学基金团队项目 |
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| 摘 要： | 目的 观察复方贞术调脂胶囊(FTZ)对代谢综合征(MS)大鼠胰岛素抵抗和胰岛素信号磷脂酰肌醇-3-激酶(PI-3K)的影响,探讨FTZ治疗MS和改善胰岛素抵抗的作用机制.方法 采用高热量饲料喂养复制MS大鼠模型,经FTZ治疗8周,测量体重、腹围、血脂、空腹血糖和胰岛素水平,RT-PCR检测脂肪组织PI-3Kp85亚基的mRNA表达水平.结果 FTZ可降低MS大鼠血清TG、TC、空腹血糖、胰岛素及胰岛素抵抗指数,升高血清HDL-C水平、减轻体重和肥胖,上调大鼠脂肪组织PI-3Kp85 mRNA的表达.结论 FTZ可调节MS大鼠糖脂水平,改善胰岛素抵抗,对MS具有防治作用.FTZ上调胰岛素信号PI-3K,可能是其治疗MS和改善胰岛素抵抗的作用机制之一.
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| 关 键 词： | 复方贞术调脂胶囊 代谢综合征 胰岛素抵抗 磷脂酰肌醇-3-激酶 |
Effect of Fufang Zhengzhu Tiaozhi Capsules on Insulin Resistance and Insulin Signal PI-3K in Metabolic Syndrome Rats |
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| HU Xuguang
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GUO Jiao
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BEI Weijian
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HE Wei
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WANG Man
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LIU Shasha.Effect of Fufang Zhengzhu Tiaozhi Capsules on Insulin Resistance and Insulin Signal PI-3K in Metabolic Syndrome Rats[J].Traditional Chinese Drug Research & Clinical Pharmacology,2012,23(2):140-143. |
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| Authors: | HU Xuguang GUO Jiao BEI Weijian HE Wei WANG Man LIU Shasha |
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| Institution: | 1(1.Key Laboratory of Liver-Regulating and Lipid Decreasing Therapy for Hyperlipemia,Guangdong Pharmaceutical University,Guangzhou 510006,China;2.Key Laboratory of Liver-Regulating and Lipid Decreasing Therapy for Hyperlipemia,Grade 3 Laboratory for Lipid Metabolism,State Administration of Traditional Chinese Medicine,Guangdong Provincial Key Laboratory of Traditional Chinese Medicine for Metabolic Disease,Guanghzou University of Chinese Medicine,Guangzhou 510006,China) |
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| Abstract: | Objective To observe the effect of Fufang Zhengzhu Tiaozhi Capsules(FTZ) on insulin resistance and insulin signal phosphatidyl inositol-3-kinase(PI-3K) in the rats with the metabolic syndrome(MS) and to explore its possible metabolism.Methods High glucose food was given to MS rats for 12 weeks.On the 5th week of modeling,the rats were given high-,medium-and low-dosage FTZ for 8 weeks.The changes of rat body weight,abdominal circumference,and the levels of fasting glucose and fasting serum insulin were measured.RT-PCR was applied for the detection of expression levels of PI-3Kp85 subunit mRNA in the rat adipose tissue.Results Compared with MS model group,FTZ significantly reduced serum triglyceride(TG) and total cholesterol(TC) levels,fasting glucose,insulin,insulin resistance index and body weight,and significantly increased serum high-density lipoprotein cholesteral(HDL-C) level.FTZ also significantly up-regulated the expression of PI-3Kp85 mRNA in rat adipose tissue.Conclusion FTZ can regulate lipid levels,and improve insulin resistance MS rats.Up-regulation of insulin signal PI-3K may be one of its therapeutic mechanisms for MS and insulin resistance. |
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| Keywords: | Fufang Zhengzhu Tiaozhi Capsule Metabolic syndrome Insulin resistance Phosphatidyl inositol-3-kinase |
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