参芎补肾胶囊对轻度血管性痴呆患者的疗效及对脑神经递质的影响

目的 观察参芎补肾胶囊治疗血管性痴呆(VD)的临床疗效,并探讨其部分作用机制.方法 将符合研究要求的66例轻度VD患者随机分为治疗组47例与对照组19例,治疗组给予参芎补肾胶囊口服；对照组给予吡拉西坦片(经重新包装为胶囊)口服.两组疗程均为2个月.观察治疗前后两组患者认知能力、日常生活能力、中医证候积分和脑神经递质的变化. 结果 治疗组认知能力总有效率74.46％,对照组总有效率68.42％,两组比较差异无统计学意义(P＞0.05)；治疗组治疗后日常生活能力及中医证候积分均较治疗前明显改善(P＜0.05或P＜0.01),并且中医证候积分改善优于对照组(P＜0.05).治疗组治疗后患者全脑乙酰胆碱、多巴胺和去甲肾上腺素有明显改善作用(P＜0.05或P＜0.01),且对乙酰胆碱和去甲肾上腺素的改善作用明显优于对照组(P＜0.05).结论 参芎补肾胶囊对轻度血管性痴呆患者疗效肯定,其部分作用机制可能与改善患者脑内神经递质水平有关.

Therapeutic Effect of Shenxiong Bushen Capsule and Its Influence on the Brain Neurotransmitter of Patients with Mild Vascular Dementia

Objective To observe the therapeutic effect of Shenxiong Bushen Capsule [Capsule with Dangshen (Radix Codonopsis Pilosulae) and Chuanxiong (Rhizoma Ligustici Chuanxiong) in it for reinforcing the kidney] on the mild vascular dementia (VD) to study its functional mechanism. Methods In this random-controlled, double-bland, test 66 mild VD cases were randomized into treatment group, with 47 cases in it, and control group, with 19 cases in it. The treatment group was treated with Shenxiong Bushen Capsule, while the control group was given Piracetam (capsule shaped). The course of treatment was of 2 months. The cognitive ability, activities of daily living, scores of TCM symptoms, and brain neurotransmitter of the patients were observed and analyzed to evaluate the therapeutic effect. Results The total effective rate of cognitive ability of the treatment group was 74.46% and that of the control group was 68.42%, the difference was not significant (P>0.05). In the treatment group, activities of daily living and scores of TCM syndromes were significantly improved after treatment (P<0.05 or P<0.01), and the improvement of scores of TCM syndromes was superior to the control group (P<0.05). Shenxiong Bushen Capsule could significantly improve acetylcholine, dopamine, and noradrenaline of the whole brain (P<0.05 or P<0.01), and the treatment group was superior to the control group in the improvement of acetylcholine and noradrenaline (P<0.05). Conclusion Shenxiong Bushen Capsule is effective for the mild VD and its mechanism is possibly related with the improvement of brain neurotransmitter.