Cajal间质细胞与肠套叠关系的探讨

目的 探讨Cajal间质细胞在小儿肠套叠发生、发展中的作用.方法 应用c-kit,NSE免疫组化染色方法,分别检测肠套叠患儿套叠头端和正常对照组肠管神经丛Cajal间质细胞的分布,观察肠间质细胞的数量与分布情况.结果 肠套叠患儿套叠头端Cajal间质细胞的数量较正常对照组明显减少,且分布疏密不一,较紊乱,差异有统计学意...

Interstitial cells of Cajal in intussusception.

Objective To investigate the relationship between distribution of the ganglionic cells and interstitial cells of Cajal （ICCs）in the ileum of intussusception. Methods Twenty eases （Malel3 , female 7 ） aging from 10 day to 16 months reported . The distribution of ICCs in between the muscle layer of bowel from normal controls and intussusception patients was studied by e - kit immunohistochemistry , Antihuman c - kit serum was used for visualization of e - kit positive（ e - kit ＋ ） cells. Results In bowels form normal controls , moderate to large amount of c - kit ＋ ICCs were observed in between the muscle layers , On the contrary, the number of c - kit ＋ ICCs was remarkably reduced or even disappeared in between the muscle layers in intussusception ,Statistics showed the significant difference of c - kit, ICCs between showed the significant difference of c - kit ICCs between the segment of bowels in intussusception and that of normal controls （ P 〈 0.05 ）. Condusions Theses results suggest that lack of c - kit ICCs may lead to the bowel spasm in intussusception