| 通心络胶囊对老年睡眠期陈-施呼吸患者呼吸的影响 |
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| 引用本文： | 蔡松泉,张希龙.通心络胶囊对老年睡眠期陈-施呼吸患者呼吸的影响[J].中华老年多器官疾病杂志,2011,10(1):25-28. |
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| 作者姓名： | 蔡松泉 张希龙 |
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| 作者单位： | 1. 南京大学附属鼓楼医院神经科,南京,210008
2. 南京医科大学第一附属医院呼吸科睡眠中心,南京,210029 |
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| 摘 要： | 目的观察通心络胶囊对老年睡眠期陈-施呼吸（CSR）患者的影响。方法根据多导睡眠图监测（PSG）结果，除外心力衰竭病因者，入选老年睡眠期CSR患者30例，按呼吸暂停低通气指数分为轻度（n=11）、中度（n=9）及重度（n=10）CSR组，均予口服通心络胶囊2粒／次，3次，d，共30d。分析治疗前后PSG指标及症状的变化及与日间嗜睡程度的相关关系。日间嗜睡程度以Epworth嗜睡评分（ESS）评定。结果通心络胶囊治疗前后比较显示，3组中仅重度组呼吸暂停低通气指数显著降低（37．4±4．3）vs（30．8±4．5），P〈0．05]；3组的日间ESS均有改善（P〈0．05），轻度组由（8．8±2．0）降低到（6．0＋1．9），中度组由（10．7±2．1）降至（8．0±2．3），重度组由（13．4±2．4）降至（10．2±3．0）。相关性分析显示轻度组ESS与微觉醒指数呈正相关（r=0．775，P〈0．05），而中重度组日间嗜睡评分与最低血氧饱和度呈负相关（分别为r=-0．751，P〈0．05；r=-0．739，P〈0．05）。结论通心络胶囊可改善老年睡眠期CSR者的日间嗜睡症状，可能部分降低重度老年睡眠期CSR的呼吸暂停低通气指数。
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| 关 键 词： | 老年人 陈-施呼吸 日间嗜睡 通心络 |
Effects of Tongxinluo capsules on respiration of the elderly with CheyneStoke respiration during sleep |
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| Cai Songquan,Zhang Xilong.Effects of Tongxinluo capsules on respiration of the elderly with CheyneStoke respiration during sleep[J].Chinrse journal of Multiple Organ Diseases in the Elderly,2011,10(1):25-28. |
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| Authors: | Cai Songquan Zhang Xilong |
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| Institution: | 1 Department of Neurology,Affiliated Drum Tower Hospital of Nanjing University,Nanjing 210008;2 Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China) |
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| Abstract: | Objective To observe the effects of Tongxinluo capsules on the elderly patients with Cheyne-Stoke respiration （CSR） during sleep. Methods According to the results of polysomnography, 30 elderly patients with nocturnal CSR but without heart failure were recruited and divided into mild （n=ll）, moderate （n=9） and severe （n=10） CSR groups. Tongxinluo was used at the dosage of 2 capsules each time, three times a day for successive 30 days. Epworth sleepiness score （ESS）, polysomnographic parameters, and clinical features were compared before and after the treatment. Their correlation with daytime sleepiness was analyzed. Results Apnea-hypopnea index（AHI） was statistically decreased after treatment only in severe CSR group （37.4±4.3） vs （30.8±4.5）, P〈0.05]. ESS showed a significant improvement in all groups （8.8±2.0） vs （6.0±1.9） in mild CSR group; （10.7±2.1） vs （8.0±2.3） in moderate CSR group and （13.4±2.4） vs （10.2±3.0） in severe CSR group, P〈0.05]. Correlation analysis demonstrated that the ESS was positively correlated with arousal index in mild CSR group（r =0.775, P〈0.05）, and negatively correlated with the mininal oxygen saturation in moderate and severe CSR groups （r = -0.751, -0.739 respectively, P〈0.05）. Conclusions Tongxinluo capsules could alleviate excessive daytime sleepiness in the elderly with CSR during sleep, and might partially reduce the AHI in the elderly with severe CSR. |
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| Keywords: | aged Cheyne Stoke respiration excessive daytime sleepiness Tongxinluo |
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