低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值对冠心病的诊断价值的探讨

目的：探讨低密度脂蛋白脂固醇（LDL－C）／高密度脂蛋白胆固醇（HDL－C）比值对冠心病（CHD）的诊断价值。方法：分析397例经冠状动脉造影确诊为冠心病的患者（CHD组）及253例冠状动脉造影阴性者（对照组）的LDL－C／HDL－C比值水平与冠心病之间的关系。结果：CHD组的LDL－C／HDL－C比值水平及异常率均明显高于对照组（P＜0．01）。相关分析显示，与三酰甘油（TG）、总胆固醇（Tch）、LDL－C和HDL－C相比，该比值显示了更有意义的相关关系（β＝0．346，P＝0．01）。经多元逐步回归分析显示，与TG、Tch、LDL－C和HDL－C相比，该比值显示了更有意义的回归关系，标准化方程式为：Y（CHD）＝0．337（糖尿病史）＋0．267（LDL－C／HDL－C）＋0.185（高血压史）（P＜0．05，复相关系数为0．525）。结论：LDL－C／HDL－C比值是诊断冠心病的一项有临床使用价值的指标。

The predictive palue of LDL-C/HDL-C ratio in coronary heart disease risk

Objective To appraise the significance of serum low density lipoprotein cholesterol/high density lipoprotein cholesterol (LDL C/HDL C) ratio in predicting coronary heart disease (CHD) risk. Methods LDL C/HDL C ratio was analysed in 645 patients who underwent coronary arteriogaphy (CHD showing positive in 392 patients and negative in 253 cases as control group). Results The level and abnormal rates of LDL C/HDL C ratio were significantly higher in patients with CHD than in those of the control group ( P <0.01). Multivariate regression analysis revealed that LDL C/HDL C ratio was a significant variable associated with CHD compared with either Tch or TG as well as LDL C or HDL C. Conclusion High LDL C/HDL C ratio is much more valuable in diagnosis of CHD than any single blood lipid abnormality, and it is a better predicting index for risk of CHD.