青年老年乳腺癌临床病理资料与预后的探讨

目的 探讨青年和老年女性乳腺癌患者的临床特征与预后的关系。方法回顾性研究2005年1月至2007年1月新疆肿瘤医院和新疆奎屯农七师医院收治的83例青年女性乳腺癌患者（≤35岁）及92例老年女性乳腺癌（≥65岁）的临床和病理资料，比较无瘤生存率（DFS）的差异。两组临床数据（淋巴结转移、浸润性导管癌、ER、PR、C—erbB-2、P53、手术方式、是否放、化疗、内分泌治疗）比较采用）（。检验；肿瘤直径、肿瘤分期采用秩和检验；生存分析采用Kaplan．Meier法，以P〈0．05为差异有统计学意义。结果两组患者在肿块大小、腋窝淋巴结转移情况、ER、C—erbB-2的差异均有统计学意义（P〈0．05）；两组患者的病理类型、PR、P53比较差异无统计学意义（P〉0．05）；两组患者治疗方式无明显差别，青年组5年的DFS低于老年，且差异具有统计学意义（P〈0．05）。结论青年乳腺癌恶性程度高并且预后差，而老年乳腺癌恶性程度较低，预后较好。

Clinico-pathological data and prognosis between young and elderly patients with breast cancer

Objective To compare the clinico-pathological data and prognosis between young and old patients with breast cancer.Methods We retrospectively analyzed the clinico-pathological data of 83 young breast cancer patients(≤35 years) and 92 elderly breast cancer patients(≤65 years) in Xinjiang Cancer Hospital and the Seventh Agriculture Division Hospital of Kuitun from January 2005 to January 2007 in order to compare the disease-free survival(DFS).The clinical data in the two groups(including lymph node metastasis,invasive ductal carcinoma,ER and PR,C-erbB-2,p53,surgical approach,radiotherapy,chemotherapy,and endocrine therapy) were compared using the χ2 test.The tumor size and tumor stage were compared using the rank sum test.Survival analysis was performed using Kaplan-Meier method.P<0.05 was considered as statistical difference.Results There were significant differences on tumor size,lymph node metastasis,ER,PR and C-erbB-2 expression between the young patients and the elderly patients(P<0.05),while no statistical difference was present on pathological type,PR and P53(P>0.05).The two groups showed no significant difference in surgical approach.The 5-year DFS in the young patients was significantly lower than that of the elderly patients(P<0.05).Conclusion Compared with young patients,the elderly breast cancer patients showed less malignancy and better prognosis.