Dominant genes for colorectal cancer are not rare |
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| Authors: | R. S. HOULSTON A. COLLINS J. SLACK N. E. MORTON |
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| Affiliation: | CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southampton General Hospital, Southampton SO9 4XY |
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| Abstract: | The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0·006 with a lifetime penetrance of 0·63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies. |
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