Is type I alpha 2 collagen gene responsible for intracranial aneurysm in Northeast China? |
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作者姓名: | Pengfei Wu Bo Li Anhua Wu Yunjie Wang |
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作者单位: | Department of Neurosurgery, First Affiliated Hospital of China Medical University;Department of Developmental Biology, Key Laboratory of Cell Biology, Ministry of Public Health of China, China Medical University |
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摘 要: | In this study, we investigated whether a single nucleotide polymorphism (rs42524 G > C) in the type Ⅰ alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G > C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC + CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was > 3. In addition, the rs42524 G > C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type Ⅰ alpha 2 collagen gene gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.
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关 键 词: | neural regeneration clinical practice intracranial aneurysm type Ⅰ collagen gene single nucleotide polymorphism polymerase chain reaction-restriction fragment length polymorphism assay susceptibility risk factors neuroregeneration |
收稿时间: | 2012 Aug 7 |
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