| HIF-1α和STAT3在胃癌中的表达及临床意义 |
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| 引用本文： | 杜子春,马利,熊兵红,程勇,张才全.HIF-1α和STAT3在胃癌中的表达及临床意义[J].中国实用医药,2013,8(5):6-8. |
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| 作者姓名： | 杜子春 马利 熊兵红 程勇 张才全 |
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| 作者单位： | [1]重庆市开县镇东街道中心卫生院,405429 [2]重庆市巴南区第二人民医院内科 ,405429 [3]重庆医科大学附属第一医院普外科,405429 |
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| 摘 要： | 目的研究胃癌中的HIF-1α和STAT3的表达及相互关系,初步探讨他们在胃癌中的生物学意义。方法用免疫组织化学染色（IHC）分别检测60例胃癌组织、15例胃正常黏膜中HIF-1α和STAT3的表达水平,了解HIF-1α和STAT3表达与临床病理指标的关系,以及两者表达的相关性。结果 HIF-1α和STAT3在胃癌组织中的表达均明显高于癌旁正常组织（均P〈0.05）。HIF-1α表达与患者性别、年龄及肿瘤部位差异均无统计学意义（均P〉0.05）,与浸润深度、TNM分期、淋巴结转移相关（均P〈0.05）。STAT3蛋白表达与患者性别、年龄及肿瘤部位,差异均无统计学意义（均P〉0.05）,STAT3与浸润深度、TNM分期、淋巴结转移相关（均P〈0.05）。HIF-1α和STAT3表达呈正相关。结论 HIF-1α和STAT3的表达与胃癌生物学行为密切相关;HIF-1α和STAT3可能联合通过抑制靶PTEN基因而促进癌细胞侵袭和迁移。
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| 关 键 词： | HIF-1α STAT3 胃癌 免疫组织化学 |
The expression and clinical significance of HIF-1α and STAT3 in gastric cancer |
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| Institution: | DU Zi-chun, MA Li, XIONG Bing-hong , et al. Zhendong Street central Hospital, Kai county, Chongqing 405429, China |
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| Abstract: | Objective To study the expression of HIF-lα and STAT3 in gastric cancer, and its corre- lation with the progression of gastric cancer（GC）. Methods Expressions of gastric were detected immunohis- tochemistry （IHC） in 30 samples of GC tissue and 10 samples of normal gastric tissue, respectively. The expres- sion of HIF-lα expression was compared with the clinicopathologic parameters related to STAT3. Results The expression level of HIF-let and STAT3 was higher in GC tissue than in normal tissues （P 〈0. 05 ,respectively）. The expression of HIF-lct and STAT3 increased with lymph node metastasis and TNM stage （P 〈 0. 05, espec- tively）. The expression of HIF-lct and STAT3 was not associated with age, sex or with location of lesions （P 〉 0. 05, respectively）. Conclusion The expression level of HIF-lα and STAT3 is closely related to the biologi- cal behavior of GC. |
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| Keywords: | HIF-1α STAT3 Gastric cancer Immunohistochemistry |
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