Effects of buthionine sulfoximine and cysteine on the hepatotoxicity of butylated hydroxytoluene in rats |
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| Authors: | Y Nakagawa |
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| Institution: | Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Sir Frederick Banting Research Centre, Tunney's Pasture, Ottawa, Ont. |
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| Abstract: | Pretreatment with buthionine sulfoximine (BSO; 900 mg/kg) induced the elevation of serum GOT and GPT activities in a non-toxic dose of butylated hydroxytoluene (BHT; 250-500 mg/kg) in rats. The elevation of serum enzyme activities was accompanied by a remarked depletion of the hepatic glutathione (GSH) concentration. In contrast, pretreatment with cysteine (100-200 mg/kg) inhibited the elevation of serum enzyme activities at a toxic dose of BHT (1000 mg/kg). The effects of BSO and cysteine on BHT-induced hepatotoxicity in rats are discussed. |
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