New cytotoxic beta-carboline alkaloids from the marine bryozoan, Cribricellina cribraria. |
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| Authors: | M R Prinsep J W Blunt M H Munro |
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| Affiliation: | Department of Chemistry, University of Canterbury, Christchurch, New Zealand. |
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| Abstract: | Bioactivity-directed separations led to the isolation of the new alkaloid, 1-vinyl-8-hydroxy-beta-carboline [1], as the major cytotoxic component of the marine bryozoan Cribricellina cribraria. Another new beta-carboline alkaloid 2 with the novel sulfone structure was isolated, together with a number of known beta-carboline compounds. Cytotoxicity and antimicrobial effects are reported for these compounds and for other synthesized beta-carbolines. |
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