前列地尔联合培多普利治疗早期糖尿病肾病50例临床观察

目的观察前列地尔（PGE，）联合培多普利（ACEI类药物）治疗早期糖尿病肾病（DN）的疗效。方法将96例早期DN患者，随机分为联合治疗组50例，培多普利组46例。两组控制血压、血糖方法相同，均服用培多普利4mg，每日1次。联合治疗组同时静脉注射PGE1 10μg，每日1次，连续14d。结果联合治疗组于治疗2周后24h尿蛋白及白蛋白排泄率较治疗前明显降低（P〈O．01），同时和培多普利组相比，下降也明显（P〈0．01）；治疗3个月后尿蛋白仍维持在较低水平。培多普利组仅在治疗3月后尿蛋白较治疗前明显减少（P〈0．01）。结论在DN早期阶段，联合使用PGE．和培多普利可快速降低尿白蛋白排泄率，并使尿蛋白长期维持在较低水平．提示培多普利联合PGE1是治疗早期DN的右前肯洪．

Alprostadil Combined Perindopril in Treatment of Early Diabetic Nephropathy

[ Objective] To observe the therapeutic effects of combined treatment of aiprostadil （ PGE-1 ） with perindopril （ ACEI ） against early diabetic nephropathy （ DN ） in patients. [ Methods ] Totally 96 cases of early DN were randomly divided into combined treatment group （ 50 eases） and perindopril group （ 46 cases ）, perindopril 4rag was administrated to both 2 groups. Intravenous in- jection of PGE 110μg was administrated to combined treatment group per day for continuous 14 days. [ Results] After 2 weeks of treatment , 24-hour urine protein and albumin excretory rate were significantly decreased in combined treatment group, compared with that of pretreatment （ P 〈0.01 ）, and it also lower than that of perindopril group. After 3 months of treatment, urine protein main- tained at a low level, while that of perindopril group significantly decreased [ P 〈0.01 ）. [ Conclusion] In the early stages of DN, combined treatment with alprostadil and perindopril can quickly reduce the urinary albumin excretion rate, and makes the urine pro- tein maintain at a low level which indicates that perindopril combined PGE-I is an effective treatment of early DN.