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Microneedle-Based Transcutaneous Immunisation in Mice with N-Trimethyl Chitosan Adjuvanted Diphtheria Toxoid Formulations

Authors:	Suzanne M Bal Zhi Ding Gideon F A Kersten Wim Jiskoot Joke A Bouwstra

Institution:	(1) Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands;(2) Department of Research and Development, Netherlands Vaccine Institute, Bilthoven, The Netherlands;(3) Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, PO Box 9502, 2300, RA, Leiden, The Netherlands;

Abstract:	Purpose The purpose of this study was to gain insight into the delivery and immunogenicity of N-trimethyl chitosan (TMC) adjuvanted diphtheria toxoid (DT) formulations applied transcutaneously with microneedles.

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