实体肿瘤内毛细血管-跨毛细血管壁-组织间质相耦合的不定常流动及对药物传递的影响

目的研究实体肿瘤内毛细血管-跨毛细血管壁-组织间质内流体不定常耦合流动对流场的影响及对药物传递的促进作用。方法建立耦合流动模型,毛细血管内流动遵循Navier-Stokes方程;跨血管壁和间质内组织液流动遵循Starling定律和Darcy定律。在边值阶跃增压和叠加脉动流两种情况下研究不定常流动,半解析半数值求解。结果相对于毛细血管,组织间质内压强传递具有滞后性。血管内流动改变引起肿瘤组织结构的动态调整,该过程中跨壁压差与组织间质压梯度均有所提高。结论毛细血管边值阶跃增压产生的不定常流动有助于药物从管壁渗出进入组织内部,也有助于其在组织内扩散。

Intracapillary-transcapillary-interstitial unsteady coupling flow in solid tumor and its influence on drug delivery

Objective To study the influence of intracapillary-transcapillary-interstitial unsteady coupling flow on the whole flow field and drug delivery in solid tumor. Methods Develop coupled fluid flow model. Intracapillary flow is governed by Navier-Stokes equations, transcapillary and interstitial fluid flow are described by Starling's law and Darcy's law respectively. Simulate the unsteady flow caused by step increase of capillary pressure and pulsating analytically and numerically. Results Relative to intracapillary, transport of pressure in the interstitium has hysteresis effect. The change of intracapillary flow will arise transient redistribution of interstitial fluid, and as a result, transcapillary pressure and interstitial pressure gradient will be increased. Conclusion Unsteady flow could increase transmural transport of drug and convective diffusion in tumor tissues as well.