| 有机锗蒽醌酰胺和有机锗萘酚酯倍半氧化物的合成及对体外培养癌细胞的抑制作用 |
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| 引用本文： | 上官国强,李雪,赵灿.有机锗蒽醌酰胺和有机锗萘酚酯倍半氧化物的合成及对体外培养癌细胞的抑制作用[J].济宁医学院学报,2009,32(2):77-80. |
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| 作者姓名： | 上官国强 李雪 赵灿 |
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| 作者单位： | 济宁医学院药学院 |
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| 摘 要： | 提要目的合成更强抗癌活性的有机锗化合物，研究分子结构和抗癌活性之间的关系。方法首先合成了4种含蒽醌酰胺和萘酯基团的新型有机锗化合物，用IR，1HNMR和元素分析研究它们的结构。用MTT方法研究化合物对人白血病癌细胞（K562）的抑制作用。结果4种化合物对K562的IC50分别为11．2，16．3，4．8，9．3μmol／L。而参照物2-氨基蒽醌和1-萘酚的IC50分别为771和282μmol／L，Ge-132对体外培养细胞几乎没有抑制作用。结论对Ge-132进行结构修饰，合成的新型有机锗化合物具有抑制体外培养癌细胞增殖的作用。
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| 关 键 词： | 有机锗倍半氧化物 2-氨基蒽醌 1-萘酚 合成 细胞毒性 |
The Synthesis and Cytotoxic Activity of Organogermanium Sesquioxides with Anthraquinone or Naphthalene Moiety |
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| SHANGGUAN Guoqiang,LI Xue,ZHAO Can.The Synthesis and Cytotoxic Activity of Organogermanium Sesquioxides with Anthraquinone or Naphthalene Moiety[J].Jounal of Jinning Medical College,2009,32(2):77-80. |
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| Authors: | SHANGGUAN Guoqiang LI Xue ZHAO Can |
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| Institution: | School of Pharmacy;Jining Medical College |
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| Abstract: | Objective To synthesize new organogermanium compounds with stronger cytotoxic activities,and study the relationship between the structure and anticancer activity.Methods Four organogermanium compounds with anthraquinone or naphthalene moiety were synthesized,their structures were determined by IR,1HNMR,and elemental analysis.Their cytotoxicity were evaluated against human chronic myeloid leukemia K562 cell lines.The experiments were repeated three times.Results The antiproliferative effect was assayed by de... |
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| Keywords: | Organogermanium sesquioxide 2-amino-anthraquinone 1-naphtol Synthesis Cytotoxicity |
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